General Information:

Id: 6,140 (click here to show other Interactions for entry)
Diseases: Colorectal cancer - [OMIM]
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
HCT116/L-OHP cells
article
Reference: Wang Z et al.Resveratrol induces AMPK-dependent MDR1 inhibition in colorectal cancer HCT116/L-OHP cells by preventing activation of NF-kappaB signaling and suppressing cAMP-responsive element transcriptional activity [PMID: 26124005]

Interaction Information:

Comment Downregulation of MDR1 expression and promoter activity was mediated by resveratrol-induced AMP-activated protein kinase (AMPK) phosphorylation. The inhibitory effects of resveratrol on MDR1 expression and cAMP-responsive element-binding protein (CREB) phosphorylation were reversed by AMPKalpha siRNA transfection. The transcriptional activity of cAMP-responsive element (CRE) was inhibited by resveratrol. These results demonstrated that the inhibitory effects of resveratrol on MDR1 expression in HCT116/L-OHP cells were closely associated with the inhibition of NF-kappaB signaling and CREB activation in an AMPK-dependent manner.
Formal Description
Interaction-ID: 57513

drug/chemical compound

Resveratrol

increases_activity of

complex/PPI

AMPK

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