General Information:

Id: 6,140
Diseases: Colorectal cancer - [OMIM]
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
HCT116/L-OHP cells
article
Reference: Wang Z et al.Resveratrol induces AMPK-dependent MDR1 inhibition in colorectal cancer HCT116/L-OHP cells by preventing activation of NF-kappaB signaling and suppressing cAMP-responsive element transcriptional activity [PMID: 26124005]

Interaction Information:

Comment Resveratrol, a natural polyphenolic compound found in foods and beverages, has attracted increasing attention in recent years because of its potent chemopreventive and anti-tumor effects. In this study, the effects of resveratrol on the expression of P-glycoprotein/multi-drug resistance protein 1 (P-gp/MDR1), and the underlying molecular mechanisms, were investigated in oxaliplatin (L-OHP)-resistant colorectal cancer cells (HCT116/L-OHP). Resveratrol downregulated MDR1 protein and mRNA expression levels and reduced MDR1 promoter activity.
Formal Description
Interaction-ID: 57466

drug/chemical compound

Resveratrol

decreases_expression of

gene/protein

ABCB1

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Comment Resveratrol enhanced the intracellular accumulation of rhodamine 123, suggesting that resveratrol can reverse multi-drug resistance by downregulating MDR1 expression and reducing drug efflux.
Formal Description
Interaction-ID: 57508

drug/chemical compound

Resveratrol

increases_quantity of

drug/chemical compound

Rhodamine 123

via decreased export
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Comment Resveratrol enhanced the intracellular accumulation of rhodamine 123, suggesting that resveratrol can reverse multi-drug resistance by downregulating MDR1 expression and reducing drug efflux.
Formal Description
Interaction-ID: 57509

drug/chemical compound

Resveratrol

decreases_activity of

process

drug export

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Comment Resveratrol treatment also reduced nuclear factor-kappaB (NF-kappaB) activity, reduced phosphorylation levels of IkappaBalpha, and reduced nuclear translocation of the NF-kappaB subunit p65.
Formal Description
Interaction-ID: 57510

drug/chemical compound

Resveratrol

decreases_activity of

complex/PPI

NF-kappaB complex

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Comment Resveratrol treatment also reduced nuclear factor-kappaB (NF-kappaB) activity, reduced phosphorylation levels of IkappaBalpha, and reduced nuclear translocation of the NF-kappaB subunit p65.
Formal Description
Interaction-ID: 57511

drug/chemical compound

Resveratrol

increases_activity of

gene/protein

NFKBIA

via decreased phosphorylation
Drugbank entries Show/Hide entries for Resveratrol
Comment Resveratrol treatment also reduced nuclear factor-kappaB (NF-kappaB) activity, reduced phosphorylation levels of IkappaBalpha, and reduced nuclear translocation of the NF-kappaB subunit p65.
Formal Description
Interaction-ID: 57512

drug/chemical compound

Resveratrol

decreases_activity of

gene/protein

RELA

via decreased translocation into the nucleus
Drugbank entries Show/Hide entries for Resveratrol or RELA
Comment Downregulation of MDR1 expression and promoter activity was mediated by resveratrol-induced AMP-activated protein kinase (AMPK) phosphorylation. The inhibitory effects of resveratrol on MDR1 expression and cAMP-responsive element-binding protein (CREB) phosphorylation were reversed by AMPKalpha siRNA transfection. The transcriptional activity of cAMP-responsive element (CRE) was inhibited by resveratrol. These results demonstrated that the inhibitory effects of resveratrol on MDR1 expression in HCT116/L-OHP cells were closely associated with the inhibition of NF-kappaB signaling and CREB activation in an AMPK-dependent manner.
Formal Description
Interaction-ID: 57513

drug/chemical compound

Resveratrol

increases_activity of

complex/PPI

AMPK

Drugbank entries Show/Hide entries for Resveratrol
Comment Downregulation of MDR1 expression and promoter activity was mediated by resveratrol-induced AMP-activated protein kinase (AMPK) phosphorylation. The inhibitory effects of resveratrol on MDR1 expression and cAMP-responsive element-binding protein (CREB) phosphorylation were reversed by AMPKalpha siRNA transfection. The transcriptional activity of cAMP-responsive element (CRE) was inhibited by resveratrol. These results demonstrated that the inhibitory effects of resveratrol on MDR1 expression in HCT116/L-OHP cells were closely associated with the inhibition of NF-kappaB signaling and CREB activation in an AMPK-dependent manner.
Formal Description
Interaction-ID: 57514

drug/chemical compound

Resveratrol

decreases_phosphorylation of

gene/protein

CREB1

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