General Information:

Id: 614
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
article
Reference: Kang DE et al.(2002) Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis Cell 110: 751-762 [PMID: 12297048]

Interaction Information:

Comment PS1 acts as a negative regulator of the Wnt/beta-catenin signaling pathway.
Formal Description
Interaction-ID: 3248

gene/protein

PSEN1

decreases_activity of

Comment Presenilin functions as a scaffold that rapidly couples beta-catenin (CTNNB1) phosphorylation through two sequential kinase activities independent of the Wnt-regulated Axin/CK1alpha complex.
Formal Description
Interaction-ID: 3288

gene/protein

PSEN1

affects_phosphorylation of

gene/protein

CTNNB1

Drugbank entries Show/Hide entries for CTNNB1
Comment Presenilin deficiency selectively reduces turnover of S45 phosphorylated beta-catenin.
Formal Description
Interaction-ID: 3292

phenotype

PSEN deficiency

affects_quantity of

protein modification

CTNNB1-phosSer45

Comment Wnt signaling rapidly decreased the steady-state levels of P-33/37/41 (=phosphorylated at positions 33, 37, and 41) but not P-45 (=S45-phosphorylated) beta-catenin resulting in accumulation of cytosolic beta-catenin.
Formal Description
Interaction-ID: 3294

decreases_quantity of

protein modification

CTNNB1-phosSer33Ser37Thr41

(= sequentially phosphorylated CTNNB1 at sites 33,37,41)
Comment Wnt signaling rapidly decreased the steady-state levels of P-33/37/41 (=phosphorylated at positions 33, 37, and 41) but not P-45 (=S45-phosphorylated) beta-catenin resulting in accumulation of cytosolic beta-catenin.
Formal Description
Interaction-ID: 3299

NOT decreases_quantity of

protein modification

CTNNB1-phosSer45

Comment PS1 strongly promotes GSK3B-dependent sequential phosphorylation of Thr41, Ser37, and Ser33, starting presumably from a GSK3B-independent priming event on S45.
Formal Description
Interaction-ID: 3307

gene/protein

GSK3B

increases_phosphorylation of

gene/protein

CTNNB1

Drugbank entries Show/Hide entries for GSK3B or CTNNB1
Comment PS1 strongly promotes GSK3B-dependent sequential phosphorylation of Thr41, Ser37, and Ser33, starting presumably from a GSK3B-independent priming event on S45.
Formal Description
Interaction-ID: 3309

gene/protein

PSEN1

increases_quantity of

protein modification

CTNNB1-phosSer33Ser37Thr41

Comment beta-Catenin is part of the canonical Wnt/beta-catenin signaling pathway.
Formal Description
Interaction-ID: 45038

gene/protein

CTNNB1

increases_activity of

Drugbank entries Show/Hide entries for CTNNB1