General Information:

Id: 613 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
article
Reference: Chen Y et al.(2009) Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimers amyloid peptides via up-regulating BACE1 transcription Proc. Natl. Acad. Sci. U.S.A. 106: 3907-3912 [PMID: 19237574]

Interaction Information:

Comment Intracellular beta-amyloid peptides were reduced in the presence of 1 microM, but not 0.25 microM, insulin.
Formal Description
Interaction-ID: 3297

complex/PPI

Insulin

affects_quantity of

gene/protein

Amyloid beta peptide

in the cell; depending on insulin concentration