General Information:

Id: 6,130 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
BTO:0002284 MIN-6 cell
Reference: Sato Y et al.(2014) Moderate hypoxia induces beta-cell dysfunction with HIF-1-independent gene expression changes PLoS ONE 9 [PMID: 25503986]

Interaction Information:

Comment HIF-1 activates the transcription of genes encoding glucose transporters, glycolytic enzymes, Pdk1 (encoding pyruvate dehydrogenase kinase), and Ldha (encoding lactate dehydrogenase). Expression of the HIF-1 target genes was significantly increased in the hypoxic MIN6 cells. Consistent with the changes in the gene expression of Pdk1 and Ldha, MIN6 cells under hypoxic conditions secreted more lactate.
Formal Description
Interaction-ID: 57428

increases_expression of



via HIF1A
Drugbank entries Show/Hide entries for LDHA