General Information:

Id: 6,130 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
BTO:0002284 MIN-6 cell
Reference: Sato Y et al.(2014) Moderate hypoxia induces beta-cell dysfunction with HIF-1-independent gene expression changes PLoS ONE 9 [PMID: 25503986]

Interaction Information:

Comment It has been demonstrated that beta-cells become hypoxic under high glucose conditions due to increased oxygen consumption and that the pancreatic islets of diabetic mice but not those of control mice are moderately hypoxic. In the present study, moderate hypoxia induced a hypoxic response in MIN6 cells, as evidenced by increased levels of HIF-1alpha protein and target genes. Under these conditions, a selective downregulation of Mafa, Pdx1, Slc2a2, Ndufa5, Kcnj11, Ins1, Wfs1, Foxa2, and Neurod1, which play important roles in beta-cells, was also observed in both MIN6 cells and isolated pancreatic islets.
Formal Description
Interaction-ID: 57417

decreases_expression of