General Information:

Id: 6,104 (click here to show other Interactions for entry)
Diseases: Cancer
Mammalia
review
Reference: Cole SP(2014) Multidrug resistance protein 1 (MRP1, ABCC1), a multitasking ATP-binding cassette (ABC) transporter J. Biol. Chem. 289 [PMID: 25281745]

Interaction Information:

Comment Perhaps the best characterized endogenous conjugated organic anion (OA) substrates of MRP1 are glutathione (GSH) and glucuronide conjugates, leukotriene C4 (LTC4) and 17-beta-estradiol 17-(beta-D-glucuronide) (E2-17betaG), respectively. In addition, the sulfated steroids estrone sulfate and dehydroepiandrostenedione sulfate are transported by MRP1. Transport of the latter two conjugates is distinguished by its dependence on GSH.
Formal Description
Interaction-ID: 57190

gene/protein

ABCC1

increases_transport of

drug/chemical compound

Glutathione

Drugbank entries Show/Hide entries for ABCC1 or Glutathione