General Information:

Id: 607 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Rattus norvegicus
BTO:0001279 spinal cord
Reference: Kaneko S et al.(2006) A selective Sema3A inhibitor enhances regenerative responses and functional recovery of the injured spinal cord. Nat. Med. 12: 1380-1389 [PMID: 17099709]

Interaction Information:

Comment Rats treated with the selective inhibitor of Sema3A, SM-216289 showed substantially enhanced regeneration and/or preservation of injured axons, robust Schwann cell-mediated myelination and axonal regeneration in the lesion site, appreciable decreases in apoptotic cell number and marked enhancement of angiogenesis, resulting in considerably better functional recovery.
Formal Description
Interaction-ID: 3209



increases_activity of