General Information:

Id: 598 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mus musculus
Reference: Cederroth CR et al.(2008) Dietary phytoestrogens activate AMP-activated protein kinase with improvement in lipid and glucose metabolism Diabetes 57: 1176-1185 [PMID: 18420492]

Interaction Information:

Comment In peripheral tissues of soy-fed mice, especially in white adipose tissue, phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase was increased, and expression of genes implicated in peroxisomal fatty acid oxidation and mitochondrial biogenesis was upregulated. Soy-fed mice also showed reduced serum insulin levels and pancreatic insulin content and improved insulin sensitivity due to increased glucose uptake into skeletal muscle. Thus, mice fed with a soy-rich diet have improved adipose and glucose metabolism.
Formal Description
Interaction-ID: 3244


high-phytoestrogen soy-based diet

increases_activity of