CIDeRGeneral Information:
| Id: | 598 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance Obesity - [OMIM] |
| Mus musculus | |
| male | |
| article | |
| Reference: | Cederroth CR et al.(2008) Dietary phytoestrogens activate AMP-activated protein kinase with improvement in lipid and glucose metabolism Diabetes 57: 1176-1185 [PMID: 18420492] |
Interaction Information:
| Comment | In peripheral tissues of soy-fed mice, especially in white adipose tissue, phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase was increased, and expression of genes implicated in peroxisomal fatty acid oxidation and mitochondrial biogenesis was upregulated. Soy-fed mice also showed reduced serum insulin levels and pancreatic insulin content and improved insulin sensitivity due to increased glucose uptake into skeletal muscle. Thus, mice fed with a soy-rich diet have improved adipose and glucose metabolism. |
|
Formal Description Interaction-ID: 3244 |
environment high-phytoestrogen soy-based diet increases_activity of process |