General Information:

Id: 595
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
article
Reference: Kim T et al.(2009) Curcumin activates AMPK and suppresses gluconeogenic gene expression in hepatoma cells. Biochem. Biophys. Res. Commun. 388: 377-382 [PMID: 19665995]

Interaction Information:

Comment Curcuminoids (curcumin, curcumin C3 complex, and tetrahydrocurcuminoids) did not improve insulin receptor tyrosine kinase activity either in the presence or absence of insulin.
Formal Description
Interaction-ID: 3133

drug/chemical compound

Curcumin

NOT affects_activity of

complex/PPI

Insulin receptor

Comment Curcumin did not inhibit alpha-glucosidase at the concentrations tested, while curcumin C3 complex, and tetrahydrocurcuminoids (THC) demonstrated modest inhibition of alpha-glucosidase at higher concentrations.
Formal Description
Interaction-ID: 3134

drug/chemical compound

Curcumin

NOT decreases_activity of

gene/protein

Alpha glucosidase

Comment Curcuminoids failed to inhibit dipeptidyl peptidase (DPP4) activity at lower concentrations.
Formal Description
Interaction-ID: 3143

drug/chemical compound

Curcumin

NOT decreases_activity of

gene/protein

DPP4

Drugbank entries Show/Hide entries for DPP4
Comment Curcuminoids suppressed dexamethasone-induced phosphoenol pyruvate carboxy kinase (PEPCK) and glucose 6-phosphatase (G6Pase) in H4IIE rat hepatoma and Hep3B human hepatoma cells.
Formal Description
Interaction-ID: 3144

drug/chemical compound

Curcumin

affects_activity of

gene/protein

PCK1

in H4IIE rat hepatoma and Hep3B human hepatoma cells
Drugbank entries Show/Hide entries for PCK1
Comment Curcuminoids increased the phosphorylation of AMP-activated protein kinase (AMPK) and its downstream target acetyl-CoA carboxylase (ACC) in H4IIE and Hep3B cells with 400 times (curcumin) to 100,000 times (THC) the potency of metformin.
Formal Description
Interaction-ID: 3147

drug/chemical compound

Curcumin

increases_phosphorylation of

complex/PPI

AMPK

in H4IIE and Hep3B cells
Comment Curcuminoids increased the phosphorylation of AMP-activated protein kinase (AMPK) and its downstream target acetyl-CoA carboxylase 2 (ACC2) in H4IIE and Hep3B cells with 400 times (curcumin) to 100,000 times (THC) the potency of metformin.
Formal Description
Interaction-ID: 3148

drug/chemical compound

Curcumin

increases_phosphorylation of

gene/protein

ACACB

in H4IIE and Hep3B cells
Drugbank entries Show/Hide entries for ACACB
Comment AMPK mediated suppression of hepatic gluconeogenesis may be a potential mechanism mediating glucose-lowering effects of curcuminoids.
Formal Description
Interaction-ID: 3150

complex/PPI

AMPK

decreases_activity of

process

gluconeogenesis

in liver
Comment Curcuminoids suppressed dexamethasone-induced phosphoenol pyruvate carboxy kinase (PEPCK) and glucose 6-phosphatase (G6Pase) in H4IIE rat hepatoma and Hep3B human hepatoma cells.
Formal Description
Interaction-ID: 12849

drug/chemical compound

Curcumin

affects_activity of

gene/protein

G6PC

in H4IIE rat hepatoma and Hep3B human hepatoma cells