General Information:

Id: 5,910 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Hemochromatosis, type 1 - [OMIM]
Insulin resistance
Mammalia
review
Reference: [PMID: 19058322]

Interaction Information:

Comment The hemochromatosis protein HFE was shown to physically interact with transferrin receptor 1 (TfR1) and impair the uptake of transferrin-bound iron in cells.
Formal Description
Interaction-ID: 55825

gene/protein

HFE

affects transport of

drug/chemical compound

Iron

Comment Duodenal enterocytes absorb dietary iron via DMT1 and reticuloendothelial macrophages phagocytose iron-loaded senescent red blood cells.
Formal Description
Interaction-ID: 55838

process

phagocytosis

increases_quantity of

drug/chemical compound

Iron

in reticuloendothelial macrophages; via phagocytosis of iron-loaded senescent red blood cells