General Information:

Id: 58 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type I - [OMIM]
Rattus norvegicus
BTO:0001185 RINm5F cell
article
Reference: Song MY et al.(2009) Sulforaphane protects against cytokine- and streptozotocin-induced beta-cell damage by suppressing the NF-kappaB pathway. Toxicol. Appl. Pharmacol. 235: 57-67 [PMID: 19071154]

Interaction Information:

Comment Cytokine (Il-1-beta and IFN-gamma) treatment induced oxidative stress analysed by H(2)O(2) formation.
Formal Description
Interaction-ID: 187

gene/protein

IL1B

increases_quantity of

drug/chemical compound

H2O2

Drugbank entries Show/Hide entries for IL1B
Comment H(2)O(2) production was abolished when RIN cells were either pretreated with SFN or transfected with Nrf2 before incubation with cytokines.
Formal Description
Interaction-ID: 189

drug/chemical compound

Sulforaphane

decreases_quantity of

drug/chemical compound

H2O2

in cytokine treated cells
Comment H(2)O(2) production was abolished when RIN cells were either pretreated with SFN or transfected with Nrf2 before incubation with cytokines.
Formal Description
Interaction-ID: 190

gene/protein

NFE2L2

decreases_quantity of

drug/chemical compound

H2O2

if Nrf2 is overexpressed in cytokine treated cells