General Information:

Id: 5,879 (click here to show other Interactions for entry)
Diseases: Lung disease
Pulmonary hypertension
Homo sapiens
Bmpr2(del)Ex2/+, 8-10 week-old
lung
article
Reference: Frank DB et al.(2008) Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculature Am. J. Physiol. Lung Cell Mol. Physiol. 294: L98-L109 [PMID: 18024717]

Interaction Information:

Comment Mean RV systolic pressure measurements and RV weights in Bmpr2(del)Ex2/+ mutant were significantly increased after 5 wk at 10% oxygen compared to wild-type littermates.
Formal Description
Interaction-ID: 55546

increases_activity of

Comment Expression of phospho-Smad1/5/8 was significantly increased in wild-type mice exposed to hypoxia for 4 days, while phospho-p38 MAPK expression was decreased. Both responses were reduced in hypoxic Bmpr2(del)Ex2/+ mutant mouse lungs.
Formal Description
Interaction-ID: 55548

increases_phosphorylation of

gene/protein

SMAD1

thereby increasing SMAD activity
Comment Expression of phospho-Smad1/5/8 was significantly increased in wild-type mice exposed to hypoxia for 4 days, while phospho-p38 MAPK expression was decreased. Both responses were reduced in hypoxic Bmpr2(del)Ex2/+ mutant mouse lungs.
Formal Description
Interaction-ID: 55549

increases_phosphorylation of

gene/protein

SMAD5

thereby increasing SMAD activity
Comment Expression of phospho-Smad1/5/8 was significantly increased in wild-type mice exposed to hypoxia for 4 days, while phospho-p38 MAPK expression was decreased. Both responses were reduced in hypoxic Bmpr2(del)Ex2/+ mutant mouse lungs.
Formal Description
Interaction-ID: 55550

increases_phosphorylation of

gene/protein

SMAD9

thereby increasing SMAD activity
Comment Expression of phospho-Smad1/5/8 was significantly increased in wild-type mice exposed to hypoxia for 4 days, while phospho-p38 MAPK expression was decreased. Both responses were reduced in hypoxic Bmpr2(del)Ex2/+ mutant mouse lungs.
Formal Description
Interaction-ID: 55551

decreases_phosphorylation of

gene/protein

p38 MAPK

Comment eNOS expression is regulated by hypoxia-induced BMP signaling in pulmonary endothelial cells. This response is defective in pulmonary endothelial cells from Bmpr2(del)Ex2/+ mutant mice.
Formal Description
Interaction-ID: 55554

increases_activity of

gene/protein

BMPR2

Comment eNOS expression is regulated by hypoxia-induced BMP signaling in pulmonary endothelial cells. This response is defective in pulmonary endothelial cells from Bmpr2(del)Ex2/+ mutant mice.
Formal Description
Interaction-ID: 55556

increases_activity of

Comment Pulmonary eNOS was upregulated by hypoxia in wild-type mice, but this response was abrogated in Bmpr2(del)Ex2/+ mutants. This was associated with a corresponding increase in iNOS expression in hypoxic Bmpr2(del)Ex2/+ mutant lungs.
Formal Description
Interaction-ID: 55606

increases_quantity of

gene/protein

NOS3

Drugbank entries Show/Hide entries for NOS3
Comment Pulmonary eNOS was upregulated by hypoxia in wild-type mice, but this response was abrogated in Bmpr2(del)Ex2/+ mutants. This was associated with a corresponding increase in iNOS expression in hypoxic Bmpr2(del)Ex2/+ mutant lungs.
Formal Description
Interaction-ID: 55607

increases_quantity of

gene/protein

NOS2

Drugbank entries Show/Hide entries for NOS2