General Information:

Id: 5,879 (click here to show other Interactions for entry)
Diseases: Lung disease
Pulmonary hypertension
Homo sapiens
Bmpr2(del)Ex2/+, 8-10 week-old
lung
article
Reference: Frank DB et al.(2008) Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculature Am. J. Physiol. Lung Cell Mol. Physiol. 294: L98-L109 [PMID: 18024717]

Interaction Information:

Comment Expression of phospho-Smad1/5/8 was significantly increased in wild-type mice exposed to hypoxia for 4 days, while phospho-p38 MAPK expression was decreased. Both responses were reduced in hypoxic Bmpr2(del)Ex2/+ mutant mouse lungs.
Formal Description
Interaction-ID: 55549

increases_phosphorylation of

gene/protein

SMAD5

thereby increasing SMAD activity