General Information:

Id: 5,868 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
review
Reference: Teperino R et al.(2014) Canonical and non-canonical Hedgehog signalling and the control of metabolism Semin. Cell Dev. Biol. 33: 81-92 [PMID: 24862854]

Interaction Information:

Comment Sufu is a critical negative pathway regulator in vertebrate Hedgehog signalling and prevents nuclear translocation of Gli proteins. As a consequence of Sufu degradation and Gli-Sufu dissociation, Gli activator forms translocate to the nucleus and activate the expression of target genes, which includes a self-amplifying loop via induction of Gli1 itself.
Formal Description
Interaction-ID: 55475

gene/protein

SUFU

decreases_activity of

process

smoothened signaling pathway