General Information:

Id: 5,868 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
review
Reference: Teperino R et al.(2014) Canonical and non-canonical Hedgehog signalling and the control of metabolism Semin. Cell Dev. Biol. 33: 81-92 [PMID: 24862854]

Interaction Information:

Comment Recent studies suggest that binding of Hedgehog to Ptch removes the ciliary G-protein Coupled Receptor Gpr161. Gpr161 in the cilium inhibits Hedgehog signalling via PKA and Gli3 repressor formation.
Formal Description
Interaction-ID: 55473

gene/protein

GPR161

decreases_activity of

in primary cilium