General Information:

Id: 5,856
Diseases: Bardet-Biedl syndrome 17 - [OMIM]
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
article
Reference: Seo S et al.(2011) A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened PLoS Genet. 7 [PMID: 22072986]

Interaction Information:

Comment A novel protein, Leucine-zipper transcription factor-like 1 (LZTFL1), interacts with a BBS protein complex known as the BBSome and regulates ciliary trafficking of this complex.
Formal Description
Interaction-ID: 55230

gene/protein

LZTFL1

interacts (colocalizes) with

complex/PPI

BBSome

Comment LZTLF1 negatively regulates BBSome ciliary trafficking.
Formal Description
Interaction-ID: 55368

gene/protein

LZTFL1

decreases_quantity of

complex/PPI

BBSome

in primary cilium
Comment Since polydactyly is one of the cardinal features of BBS and a hallmark phenotype of Sonic Hedgehog (SHH) signaling defect, the roles of BBSome and LZTFL1 in the SHH pathway were examined. BBSome function facilitates ciliary localization of the SHH signal transducer Smoothened (SMO) and LZTFL1 suppresses SMO localization to cilia.
Formal Description
Interaction-ID: 55369

complex/PPI

BBSome

increases_quantity of

gene/protein

SMO

in primary cilium
Drugbank entries Show/Hide entries for SMO
Comment Since polydactyly is one of the cardinal features of BBS and a hallmark phenotype of Sonic Hedgehog (SHH) signaling defect, the roles of BBSome and LZTFL1 in the SHH pathway were examined. BBSome function facilitates ciliary localization of the SHH signal transducer Smoothened (SMO) and LZTFL1 suppresses SMO localization to cilia.
Formal Description
Interaction-ID: 55370

gene/protein

LZTFL1

decreases_quantity of

gene/protein

SMO

in primary cilium
Drugbank entries Show/Hide entries for SMO
Comment Since polydactyly is one of the cardinal features of BBS and a hallmark phenotype of Sonic Hedgehog (SHH) signaling defect, the roles of BBSome and LZTFL1 in the SHH pathway were examined. BBSome function facilitates ciliary localization of the SHH signal transducer Smoothened (SMO) and LZTFL1 suppresses SMO localization to cilia.
Formal Description
Interaction-ID: 55371

gene/protein

LZTFL1

affects_activity of

Comment Since polydactyly is one of the cardinal features of BBS and a hallmark phenotype of Sonic Hedgehog (SHH) signaling defect, the roles of BBSome and LZTFL1 in the SHH pathway were examined. BBSome function facilitates ciliary localization of the SHH signal transducer Smoothened (SMO) and LZTFL1 suppresses SMO localization to cilia.
Formal Description
Interaction-ID: 55372

complex/PPI

BBSome

affects_activity of