General Information:

Id: 5,841 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
article
Reference: Landsman L et al.(2011) Elevated Hedgehog/Gli signaling causes beta-cell dedifferentiation in mice Proc. Natl. Acad. Sci. U.S.A. 108 [PMID: 21969560]

Interaction Information:

Comment Hes1, a transcription factor activated by the Notch signaling pathway, is expressed in embryonic and adult pancreata but excluded from beta-cells. Pdx1-CreER;CLEG2;Kif3af/f islets showed a twofold increase in Hes1 transcript levels compared with controls, accompanied by a profound up-regulation of the Hes1 protein.
Formal Description
Interaction-ID: 55195

increases_expression of

gene/protein

HES1

in adult pancreatic beta cells