General Information:

Id: 5,841 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
article
Reference: Landsman L et al.(2011) Elevated Hedgehog/Gli signaling causes beta-cell dedifferentiation in mice Proc. Natl. Acad. Sci. U.S.A. 108 [PMID: 21969560]

Interaction Information:

Comment Sox9, whose function is required in pancreas progenitor cells, is normally excluded from mature beta-cells. Sox9 transcript and protein levels were increased twofold and fourfold, respectively, in Pdx1-CreER;CLEG2;Kif3af/f transgenic islets compared with control.
Formal Description
Interaction-ID: 55194

increases_expression of

gene/protein

SOX9

in adult pancreatic beta cells