General Information:

Id: 5,841 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
article
Reference: Landsman L et al.(2011) Elevated Hedgehog/Gli signaling causes beta-cell dedifferentiation in mice Proc. Natl. Acad. Sci. U.S.A. 108 [PMID: 21969560]

Interaction Information:

Comment Numerous studies have delineated the transcription factor network that guides beta-cell development and ensures proper beta-cell function by maintaining the fully differentiated state of the cells. To study whether the impaired GSIS observed in Pdx1-CreER;CLEG2;Kif3af/f mice was a result of the loss of the mature beta-cell phenotype, the authors analyzed the expression levels of such factors. Transgenic islets expressed lower levels of Pdx1, as shown by significant reduction of both transcript and protein levels compared with nontransgenic control. The analysis further revealed significant reduction in the expression of MafA, NeuroD1, Nkx6.1, and Neurogenin3 (Ngn3) in transgenic islets 4 wk after TAM treatment compared with control. Thus, elevated Hh signaling causes reduction of critical beta-cell markers, suggesting a loss of the mature beta-cell phenotype.
Formal Description
Interaction-ID: 55191

decreases_expression of

gene/protein

MAFA

in adult pancreatic beta cells