General Information:

Id: 5,841 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
article
Reference: Landsman L et al.(2011) Elevated Hedgehog/Gli signaling causes beta-cell dedifferentiation in mice Proc. Natl. Acad. Sci. U.S.A. 108 [PMID: 21969560]

Interaction Information:

Comment The expression level of Kir6.2 and Sur1, components of beta-cell K(ATP) channels required for insulin secretion, was analyzed. Transcript levels of both genes were significantly reduced in TAM-treated transgenic islets compared with control, suggesting potential secretion defects.
Formal Description
Interaction-ID: 55187

decreases_expression of

gene/protein

KCNJ11

in adult pancreatic beta cells
Drugbank entries Show/Hide entries for KCNJ11