General Information:

Id: 5,841 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
article
Reference: Landsman L et al.(2011) Elevated Hedgehog/Gli signaling causes beta-cell dedifferentiation in mice Proc. Natl. Acad. Sci. U.S.A. 108 [PMID: 21969560]

Interaction Information:

Comment As expected from previous work showing that elevated Hedgehog (Hh) signaling protects cultured beta-cells from apoptosis, a significant increase in the expression level of the anti-apoptotic gene Bcl2 was detected.
Formal Description
Interaction-ID: 55186

increases_expression of

gene/protein

BCL2

in adult pancreatic beta cells
Drugbank entries Show/Hide entries for BCL2