General Information:

Id: 5,841 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
article
Reference: Landsman L et al.(2011) Elevated Hedgehog/Gli signaling causes beta-cell dedifferentiation in mice Proc. Natl. Acad. Sci. U.S.A. 108 [PMID: 21969560]

Interaction Information:

Comment Increased Hedgehog (Hh) signaling leads to impaired beta-cell function and insulin secretion, resulting in glucose intolerance in transgenic mice.
Formal Description
Interaction-ID: 55185

process

smoothened signaling pathway

decreases_activity of

phenotype

reduced pancreatic beta cell function

in adult pancreatic beta cells