General Information:

Id: 580 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
article
Reference: Phiel CJ et al.(2003) GSK-3alpha regulates production of Alzheimers disease amyloid-beta peptides. Nature 423: 435-439 [PMID: 12761548]

Interaction Information:

Comment Lithium, a GSK-3 inhibitor, block the production of amyloid beta peptides by interfering with APP cleavage at the gamma-secretase step.
Formal Description
Interaction-ID: 3103

drug/chemical compound

Lithium

affects_processing of

gene/protein

APP

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