General Information:

Id: 580 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mus musculus
brain
article
Reference: Phiel CJ et al.(2003) GSK-3alpha regulates production of Alzheimers disease amyloid-beta peptides Nature 423: 435-439 [PMID: 12761548]

Interaction Information:

Comment Therapeutic concentrations of lithium block the production of amyloid beta peptides.
Formal Description
Interaction-ID: 3095

drug/chemical compound

Lithium

decreases_expression of

gene/protein

Amyloid beta peptide

Drugbank entries Show/Hide entries for Lithium
Comment Therapeutic concentrations of lithium block the production of amyloid beta peptides.
Formal Description
Interaction-ID: 3096

drug/chemical compound

Lithium

decreases_quantity of

gene/protein

Amyloid beta peptide

in brain; of mice
Drugbank entries Show/Hide entries for Lithium
Comment Gamma-secretase affects the APP processing.
Formal Description
Interaction-ID: 3104

complex/PPI

Gamma-secretase complex

increases_quantity of

gene/protein

Amyloid beta peptide

Comment Overexpression of beta-catenin did not affect amyloid beta peptide (Abeta) production (under conditions that activated the beta-catenin-dependent reporter).
Formal Description
Interaction-ID: 3136

gene/protein

CTNNB1

NOT affects_quantity of

gene/protein

Amyloid beta peptide

if CTNNB1 (beta-catenin) is overexpressed
Drugbank entries Show/Hide entries for CTNNB1