General Information:

Id: 580
Diseases: Alzheimer disease - [OMIM]
Mammalia
article
Reference: Phiel CJ et al.(2003) GSK-3alpha regulates production of Alzheimers disease amyloid-beta peptides. Nature 423: 435-439 [PMID: 12761548]

Interaction Information:

Comment GSK-3alpha regulates production of Alzheimer's disease amyloid beta peptides.
Formal Description
Interaction-ID: 3058

gene/protein

GSK3A

affects_activity of

Comment Lithium is a GSK-3 inhibitor.
Formal Description
Interaction-ID: 3093

drug/chemical compound

Lithium

decreases_activity of

gene/protein

GSK3A

Drugbank entries Show/Hide entries for Lithium
Comment Therapeutic concentrations of lithium block the production of amyloid beta peptides.
Formal Description
Interaction-ID: 3095

drug/chemical compound

Lithium

decreases_expression of

gene/protein

Amyloid beta peptide

Drugbank entries Show/Hide entries for Lithium
Comment Therapeutic concentrations of lithium block the production of amyloid beta peptides.
Formal Description
Interaction-ID: 3096

drug/chemical compound

Lithium

decreases_quantity of

gene/protein

Amyloid beta peptide

in brain; of mice
Drugbank entries Show/Hide entries for Lithium
Comment Lithium is a GSK-3 inhibitor.
Formal Description
Interaction-ID: 3097

drug/chemical compound

Lithium

decreases_activity of

gene/protein

GSK3B

Drugbank entries Show/Hide entries for Lithium or GSK3B
Comment Lithium, a GSK-3 inhibitor, block the production of amyloid beta peptides by interfering with APP cleavage at the gamma-secretase step.
Formal Description
Interaction-ID: 3103

drug/chemical compound

Lithium

affects_processing of

gene/protein

APP

Drugbank entries Show/Hide entries for Lithium or APP
Comment Gamma-secretase affects the APP processing.
Formal Description
Interaction-ID: 3104

increases_quantity of

gene/protein

Amyloid beta peptide

Comment PS1 interacts with beta-catenin, and regulates beta-catenin protein levels and subcellular localization.
Formal Description
Interaction-ID: 3125

gene/protein

PSEN1

interacts (colocalizes) with

gene/protein

CTNNB1

Drugbank entries Show/Hide entries for CTNNB1
Comment PS1 interacts with beta-catenin, and regulates beta-catenin protein levels and subcellular localization.
Formal Description
Interaction-ID: 3135

gene/protein

PSEN1

affects_quantity of

gene/protein

CTNNB1

Drugbank entries Show/Hide entries for CTNNB1
Comment Overexpression of beta-catenin did not affect amyloid beta peptide (Abeta) production (under conditions that activated the beta-catenin-dependent reporter).
Formal Description
Interaction-ID: 3136

gene/protein

CTNNB1

NOT affects_quantity of

gene/protein

Amyloid beta peptide

if CTNNB1 (beta-catenin) is overexpressed
Drugbank entries Show/Hide entries for CTNNB1
Comment GSK-3 regulates APP processing. Selective reduction of GSK-3A protein expression decreased amyloid beta40 peptide (Ab40) and amyloid beta42 peptide (Ab42) levels.
Formal Description
Interaction-ID: 3140

gene/protein

GSK3A

affects_processing of

gene/protein

APP

Drugbank entries Show/Hide entries for APP
Comment GSK-3 regulates APP processing.
Formal Description
Interaction-ID: 3141

gene/protein

GSK3B

affects_processing of

gene/protein

APP

Drugbank entries Show/Hide entries for GSK3B or APP
Comment Selective reduction of GSK-3A protein expression decreased amyloid beta40 peptide (Abeta40) and amyloid beta42 peptide (Abeta42) levels. Reduction of GSK-3B protein levels resulted in a modest increase in Abeta40 and Abeta42 concentration. The amino- and carboxyterminal sequences of GSK-3A and GSK-3B are dissimilar. This divergence may account for functional differences in the regulation of APP processing.
Formal Description
Interaction-ID: 3142

gene/protein

GSK3A

increases_quantity of

Comment Selective reduction of GSK-3A protein expression decreased amyloid beta40 peptide (Abeta40) and amyloid beta42 peptide (Abeta42) levels. Reduction of GSK-3B protein levels resulted in a modest increase in Abeta40 and Abeta42 concentration. The amino- and carboxyterminal sequences of GSK-3A and GSK-3B are dissimilar. This divergence may account for functional differences in the regulation of APP processing.
Formal Description
Interaction-ID: 26738

gene/protein

GSK3A

increases_quantity of

Comment Reduction of GSK-3B protein levels resulted in a modest increase in Abeta40 and Abeta42 concentration.
Formal Description
Interaction-ID: 64425

gene/protein

GSK3B

decreases_quantity of

Drugbank entries Show/Hide entries for GSK3B
Comment Reduction of GSK-3B protein levels resulted in a modest increase in Abeta40 and Abeta42 concentration.
Formal Description
Interaction-ID: 64426

gene/protein

GSK3B

decreases_quantity of

Drugbank entries Show/Hide entries for GSK3B