General Information:

Id: 575 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
article
Reference: Woods A et al.(2005) Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells. Cell Metab. 2: 21-33 [PMID: 16054096]

Interaction Information:

Comment Cultured mouse embryonic fibroblasts (MEFs) isolated from LKB1-/- embryos were subjected either to oxidative stress (hydrogen peroxide, H2O2) or hyperosmotic stress (sorbitol), in both cases AMPK activity was markedly increased in LKB1-/- MEFs relative to untreated cells.
Formal Description
Interaction-ID: 3013

drug/chemical compound

H2O2

increases_activity of

complex/PPI

AMPK

in LKB1-/- MEF cells