General Information:

Id: 574 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Zhou S et al.(2007) Regulation of gamma-secretase activity in Alzheimers disease. Biochemistry 46: 2553-2563 [PMID: 17298085]

Interaction Information:

Comment Glycogen synthase kinase-3 (GSK-3), phospholipase D1 (PLD1), and TMP21, have been found to affect the activity of gamma-secretase.
Formal Description
Interaction-ID: 3028

gene/protein

GSK3B

affects_activity of

complex/PPI

Gamma-secretase complex

Drugbank entries Show/Hide entries for GSK3B
Comment Soluble protein GSK-3 has been found to phosphorylate tau at many sites.
Formal Description
Interaction-ID: 3041

gene/protein

GSK3B

increases_phosphorylation of

gene/protein

MAPT

Drugbank entries Show/Hide entries for GSK3B
Comment GSK3B and TAU (MAPT) physically bind to PS1 along the same region, residues 250- 298, which suggested that PS1 may regulate the interaction of tau with GSK3B.
Formal Description
Interaction-ID: 3047

gene/protein

GSK3B

interacts (colocalizes) with

gene/protein

PSEN1

Drugbank entries Show/Hide entries for GSK3B
Comment Site-directed mutagenesis indicated that PS1 residues Ser353, Ser357, and Ser397 are GSK3B targets.
Formal Description
Interaction-ID: 3049

gene/protein

GSK3B

affects_activity of

gene/protein

PSEN1

Drugbank entries Show/Hide entries for GSK3B
Comment GSK3B participates in the Wnt signaling pathway.
Formal Description
Interaction-ID: 3050

gene/protein

GSK3B

affects_activity of

Drugbank entries Show/Hide entries for GSK3B