General Information:

Id: 560 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0000793 SH-SY5Y cell
article
Reference: Olzmann JA et al.(2007) Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6. J. Cell Biol. 178: 1025-1038 [PMID: 17846173]

Interaction Information:

Comment Parkin was able to facilitate the polyubiquitination of L166P mutant DJ-1 in the presence of wild-type ubiquitin and ubiquitin mutant Ub-K63.
Formal Description
Interaction-ID: 2940

gene/protein

PARK2

increases_ubiquitination/sumoylation of

gene/protein mutant

PARK7-p.L166P

via K63-linked ubiquitin chains