General Information:

Id: 560 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0000793 SH-SY5Y cell
article
Reference: Olzmann JA et al.(2007) Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6. J. Cell Biol. 178: 1025-1038 [PMID: 17846173]

Interaction Information:

Comment Parkin ubiquitinates DJ-1 mutant L166P, but not wild-type DJ-1, suggesting that parkin selectively recognizes and ubiquitinates misfolded DJ-1.
Formal Description
Interaction-ID: 2909

gene/protein

PARK2

increases_ubiquitination/sumoylation of

gene/protein mutant

PARK7-p.L166P