General Information:
Id: | 559 (click here to show other Interactions for entry) |
Diseases: |
Cancer
Diabetes mellitus, type II - [OMIM] Insulin resistance Peutz-Jeghers syndrome - [OMIM] |
Mammalia | |
article | |
Reference: | Shaw RJ et al.(2004) The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc. Natl. Acad. Sci. U.S.A. 101: 3329-3335 [PMID: 14985505] |
Interaction Information:
Comment | LKB1-deficient cells are hypersensitive to apoptosis induced by energy stress. |
Formal Description Interaction-ID: 2994 |
|
Comment | LKB1 protects cells from apoptosis induced by agents that elevate intracellular AMP. |
Formal Description Interaction-ID: 2997 |
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