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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	559 (click here to show other Interactions for entry)
Diseases:	Cancer Diabetes mellitus, type II - [OMIM] Insulin resistance Peutz-Jeghers syndrome - [OMIM]
Organism:	Mammalia
Publication type:	article
Reference:	Shaw RJ et al.(2004) The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc. Natl. Acad. Sci. U.S.A. 101: 3329-3335 [PMID: 14985505]

Interaction Information:

Comment	LKB1-deficient cells are hypersensitive to apoptosis induced by energy stress.
Formal Description Interaction-ID: 2994	gene/protein STK11 affects_activity of process apoptotic process

Comment	LKB1 protects cells from apoptosis induced by agents that elevate intracellular AMP.
Formal Description Interaction-ID: 2997	gene/protein STK11 decreases_activity of process apoptotic process induced by elevated AMP

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