General Information:

Id: 559 (click here to show other Interactions for entry)
Diseases: Cancer
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Peutz-Jeghers syndrome - [OMIM]
Mammalia
article
Reference: Shaw RJ et al.(2004) The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc. Natl. Acad. Sci. U.S.A. 101: 3329-3335 [PMID: 14985505]

Interaction Information:

Comment Peroxide or AICAR treatment led to activation of AMPK in vivo, which supports the model in which allosteric regulation or the AMPK heterotrimer by AMP-binding allows it to better serve as substrate for the upstream kinase, as opposed to direct regulation of the activity of the AMPK kinase by AMP.
Formal Description
Interaction-ID: 2979

drug/chemical compound

H2O2

increases_activity of

complex/PPI

AMPK

in vivo