General Information:

Id: 559 (click here to show other Interactions for entry)
Diseases: Cancer
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Peutz-Jeghers syndrome - [OMIM]
Mammalia
article
Reference: Shaw RJ et al.(2004) The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc. Natl. Acad. Sci. U.S.A. 101: 3329-3335 [PMID: 14985505]

Interaction Information:

Comment The kinase activity of LKB1 immunoprecipitated from cells treated with peroxide or AICAR was not increased compared with that from untreated control cells, as measured both by autophosphotylation and transphpsphorylation or the MBP-AMPK fusion.
Formal Description
Interaction-ID: 2975

drug/chemical compound

H2O2

NOT increases_activity of

gene/protein

STK11

Comment Peroxide or AICAR treatment led to activation of AMPK in vivo, which supports the model in which allosteric regulation or the AMPK heterotrimer by AMP-binding allows it to better serve as substrate for the upstream kinase, as opposed to direct regulation of the activity of the AMPK kinase by AMP.
Formal Description
Interaction-ID: 2979

drug/chemical compound

H2O2

increases_activity of

complex/PPI

AMPK

in vivo