General Information:

Id: 559 (click here to show other Interactions for entry)
Diseases: Cancer
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Peutz-Jeghers syndrome - [OMIM]
Mammalia
article
Reference: Shaw RJ et al.(2004) The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc. Natl. Acad. Sci. U.S.A. 101: 3329-3335 [PMID: 14985505]

Interaction Information:

Comment AMPK inactivates ACC through phosphorylation of Ser-79, thereby stimulating fatty acid oxidation. LKB1-deficient murine embryonic fibroblasts show nearly complete loss of AMPK phosphorylation and ACC phosphorylation in response to stimuli that activate AMPK (peroxide and AICAR).
Formal Description
Interaction-ID: 12836

complex/PPI

AMPK

increases_activity of

via inhibition of ACC