General Information:

Id: 5,562
Diseases: Cardiovascular
Mus musculus
Reference: Krishnan J et al.(2008) Essential role of developmentally activated hypoxia-inducible factor 1alpha for cardiac morphogenesis and function Circ. Res. 103: 1139-1146 [PMID: 18849322]

Interaction Information:

Comment HIF1alpha-deficient hearts display reduced expression of the core cardiac transcription factors Mef2C and Tbx5 and of titin, a giant protein that serves as a template for the assembly and organization of the sarcomere. Chromatin immunoprecipitation experiments revealed that Mef2C, Tbx5, and titin are direct target genes of HIF1alpha in vivo.
Formal Description
Interaction-ID: 53588



increases_expression of



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