General Information:

Id: 5,562
Diseases: Cardiovascular
Mus musculus
article
Reference: Krishnan J et al.(2008) Essential role of developmentally activated hypoxia-inducible factor 1alpha for cardiac morphogenesis and function Circ. Res. 103: 1139-1146 [PMID: 18849322]

Interaction Information:

Comment HIF1alpha-deficient hearts display reduced expression of the core cardiac transcription factors Mef2C and Tbx5 and of titin, a giant protein that serves as a template for the assembly and organization of the sarcomere. Chromatin immunoprecipitation experiments revealed that Mef2C, Tbx5, and titin are direct target genes of HIF1alpha in vivo.
Formal Description
Interaction-ID: 53588

gene/protein

HIF1A

increases_expression of

gene/protein

TTN

Drugbank entries Show/Hide entries for HIF1A