General Information:
Id: | 555 (click here to show other Interactions for entry) |
Diseases: |
Amyotrophic lateral sclerosis
|
Rattus norvegicus | |
BTO:0001264 spinal ganglion | |
article | |
Reference: | Kesavapany S et al.(2007) Inhibition of Pin1 reduces glutamate-induced perikaryal accumulation of phosphorylated neurofilament-H in neurons. Mol. Biol. Cell 18: 3645-3655 [PMID: 17626162] |
Interaction Information:
Comment | Neuronal death increased nearly four times upon exposure to glutamate, and this was reduced nearly twofold when neurons were treated with juglone before glutamate treatment. |
Formal Description Interaction-ID: 2893 |
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Comment | Neuronal death increased nearly four times upon exposure to glutamate, and this was reduced nearly twofold when neurons were treated with juglone (Pin1 inhibitor) before glutamate treatment. |
Formal Description Interaction-ID: 2894 |
drug/chemical compound decreases_activity of process |
Comment | Inhibition of Pin1 reduces glutamate mediated neuronal cell death. |
Formal Description Interaction-ID: 2895 |
gene/protein increases_activity of process |
Drugbank entries | Show/Hide entries for PIN1 |