General Information:

Id: 555 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Rattus norvegicus
BTO:0001264 spinal ganglion
article
Reference: Kesavapany S et al.(2007) Inhibition of Pin1 reduces glutamate-induced perikaryal accumulation of phosphorylated neurofilament-H in neurons. Mol. Biol. Cell 18: 3645-3655 [PMID: 17626162]

Interaction Information:

Comment Neuronal death increased nearly four times upon exposure to glutamate, and this was reduced nearly twofold when neurons were treated with juglone before glutamate treatment.
Formal Description
Interaction-ID: 2893

drug/chemical compound

Glutamate

increases_activity of

process

neuron death

in cortical neurons
Comment Neuronal death increased nearly four times upon exposure to glutamate, and this was reduced nearly twofold when neurons were treated with juglone (Pin1 inhibitor) before glutamate treatment.
Formal Description
Interaction-ID: 2894

drug/chemical compound

5-Hydroxy-1,4-naphthoquinone

decreases_activity of

process

neuron death

in cortical neurons; exposed to glutamate
Comment Inhibition of Pin1 reduces glutamate mediated neuronal cell death.
Formal Description
Interaction-ID: 2895

gene/protein

PIN1

increases_activity of

process

neuron death

in cortical neurons; exposed to glutamate
Drugbank entries Show/Hide entries for PIN1