General Information:

Id: 551 (click here to show other Interactions for entry)
Diseases: Breast cancer - [OMIM]
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Homo sapiens
female
primary human breast adipose stromal cells
article
Reference: Brown KA et al.(2009) Subcellular localization of cyclic AMP-responsive element binding protein-regulated transcription coactivator 2 provides a link between obesity and breast cancer in postmenopausal women Cancer Res. 69: 5392-5399 [PMID: 19509226]

Interaction Information:

Comment Leptin induces aromatase expression via CRTC2 translocation to the nucleus and inhibition of LKB1 expression in human adipose stromal cells.
Formal Description
Interaction-ID: 2883

gene/protein

LEP

increases_expression of

gene/protein

CYP19A1

in adipose stromal cells
Drugbank entries Show/Hide entries for CYP19A1
Comment Leptin induces aromatase expression via CRTC2 translocation to the nucleus and inhibition of LKB1 expression in human adipose stromal cells.
Formal Description
Interaction-ID: 2884

gene/protein

LEP

decreases_expression of

gene/protein

STK11

in adipose stromal cells
Comment Leptin induces aromatase expression via CRTC2 translocation to the nucleus and inhibition of LKB1 expression in human adipose stromal cells.
Formal Description
Interaction-ID: 2888

gene/protein

LEP

increases_transport of

gene/protein

CRTC2

in adipose stromal cells; into the nucleus