General Information:

Id: 5,516 (click here to show other Interactions for entry)
Diseases: Cardiomyopathy
Mus musculus
article
Reference: Wheeler MA et al.(2010) Identification of an emerin-beta-catenin complex in the heart important for intercalated disc architecture and beta-catenin localisation Cell. Mol. Life Sci. 67: 781-796 [PMID: 19997769]

Interaction Information:

Comment Emerin was identified as a direct target of GSK3beta activity since exogenous expression of GSK3beta reduced emerin levels at the nuclear envelope.
Formal Description
Interaction-ID: 53467

gene/protein

GSK3B

decreases_quantity of

gene/protein

EMD

in cardiomyocytes
Drugbank entries Show/Hide entries for GSK3B
Comment Wild type but not mutant forms of emerin associated with X-EDMD were able to reduce beta-catenin protein levels.
Formal Description
Interaction-ID: 53469

gene/protein

EMD

decreases_quantity of

gene/protein

CTNNB1

in cardiomyocytes
Drugbank entries Show/Hide entries for CTNNB1