General Information:

Id: 549
Diseases: Breast cancer - [OMIM]
Colorectal cancer - [OMIM]
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Metabolic syndrome
Obesity - [OMIM]
Mammalia
review
Reference: Brown KA and Simpson ER(2010) Obesity and breast cancer: progress to understanding the relationship Cancer Res. 70: 4-7 [PMID: 20028864]

Interaction Information:

Comment Epidemiological evidence supports a link between obesity, the metabolic syndrome, and insulin resistance with increased risk of several cancers including those of colon and the breast.
Formal Description
Interaction-ID: 2803

disease

Obesity

increases_activity of

disease

Breast cancer

Comment Epidemiological evidence supports a link between obesity, the metabolic syndrome, and insulin resistance with increased risk of several cancers including those of colon and the breast.
Formal Description
Interaction-ID: 2816

disease

Obesity

increases_activity of

Comment Epidemiological evidence supports a link between obesity, the metabolic syndrome, and insulin resistance with increased risk of several cancers including those of colon and the breast.
Formal Description
Interaction-ID: 2817

disease

Metabolic syndrome

increases_activity of

disease

Breast cancer

Comment Epidemiological evidence supports a link between obesity, the metabolic syndrome, and insulin resistance with increased risk of several cancers including those of colon and the breast.
Formal Description
Interaction-ID: 2818

disease

Metabolic syndrome

increases_activity of

Comment Epidemiological evidence supports a link between obesity, the metabolic syndrome, and insulin resistance with increased risk of several cancers including those of colon and the breast.
Formal Description
Interaction-ID: 2819

disease

Insulin resistance

increases_activity of

disease

Breast cancer

Comment Epidemiological evidence supports a link between obesity, the metabolic syndrome, and insulin resistance with increased risk of several cancers including those of colon and the breast.
Formal Description
Interaction-ID: 2820

disease

Insulin resistance

increases_activity of

Comment The use of metformin, an oral antidiabetic drug, is associated with decreased cancer risk.
Formal Description
Interaction-ID: 2821

drug/chemical compound

Metformin

decreases_activity of

disease

Cancer

Drugbank entries Show/Hide entries for Metformin
Comment Metformin stimulates AMP-activated protein kinase (AMPK).
Formal Description
Interaction-ID: 2823

drug/chemical compound

Metformin

increases_activity of

complex/PPI

AMPK

Drugbank entries Show/Hide entries for Metformin
Comment AMPK is a master regulator of energy homeostasis, it stimulates pathways of energy production (e.g. glycolysis and fatty acid beta-oxidation) and inhibits those of energy use (e.g. gluconeogenesis and fatty acid and cholesterol biosynthesis).
Formal Description
Interaction-ID: 2825

complex/PPI

AMPK

increases_activity of

Comment AMPK is a master regulator of energy homeostasis, it stimulates pathways of energy production (e.g. glycolysis and fatty acid beta-oxidation) and inhibits those of energy use (e.g. gluconeogenesis and fatty acid and cholesterol biosynthesis).
Formal Description
Interaction-ID: 2826

complex/PPI

AMPK

increases_activity of

Comment AMPK is a master regulator of energy homeostasis, it stimulates pathways of energy production (e.g. glycolysis and fatty acid beta-oxidation) and inhibits those of energy use (e.g. gluconeogenesis and fatty acid and cholesterol biosynthesis).
Formal Description
Interaction-ID: 2829

complex/PPI

AMPK

decreases_activity of

process

gluconeogenesis

Comment AMPK is a master regulator of energy homeostasis, it stimulates pathways of energy production (e.g. glycolysis and fatty acid beta-oxidation) and inhibits those of energy use (e.g. gluconeogenesis and fatty acid and cholesterol biosynthesis).
Formal Description
Interaction-ID: 2830

complex/PPI

AMPK

decreases_activity of

Comment AMPK is a master regulator of energy homeostasis, it stimulates pathways of energy production (e.g. glycolysis and fatty acid beta-oxidation) and inhibits those of energy use (e.g. gluconeogenesis and fatty acid and cholesterol biosynthesis).
Formal Description
Interaction-ID: 2831

complex/PPI

AMPK

decreases_activity of

Comment Leptin synthesis and plasma levels increase with obesity and higher leptin levels are significantly associated with an increase in breast cancer.
Formal Description
Interaction-ID: 2832

disease

Obesity

increases_quantity of

gene/protein

LEP

in blood
Comment Leptin synthesis and plasma levels increase with obesity and higher leptin levels are significantly associated with an increase in breast cancer.
Formal Description
Interaction-ID: 2834

gene/protein

LEP

affects_activity of

disease

Breast cancer

Comment Adiponectin levels in the serum decrease with increased obesity and epidemiological studies of adiponectin have shown an inverse association between serum adiponectin levels and breast cancer risk.
Formal Description
Interaction-ID: 2835

disease

Obesity

decreases_quantity of

gene/protein

ADIPOQ

in blood
Comment Adiponectin levels in the serum decrease with increased obesity and epidemiological studies of adiponectin have shown an inverse association between serum adiponectin levels and breast cancer risk.
Formal Description
Interaction-ID: 2836

gene/protein

ADIPOQ

affects_activity of

disease

Breast cancer

Comment One of the actions of AMPK is to phosphorylate and inhibit the actions of cAMP-responsive element binding protein (CREB)-regulated transcription coactivator 2 (CRTC2).
Formal Description
Interaction-ID: 2837

complex/PPI

AMPK

increases_phosphorylation of

gene/protein

CRTC2

Comment One of the actions of AMPK is to phosphorylate and inhibit the actions of cAMP-responsive element binding protein (CREB)-regulated transcription coactivator 2 (CRTC2).
Formal Description
Interaction-ID: 2838

complex/PPI

AMPK

decreases_activity of

gene/protein

CRTC2

Comment In postmenopausal women, the CREB-dependent regulation of aromatase is a crucial determinant of breast tumor formation through local production of estrogens.
Formal Description
Interaction-ID: 2839

gene/protein

CYP19A1

affects_activity of

disease

Breast cancer

in postmenopausal women
Drugbank entries Show/Hide entries for CYP19A1
Comment The regulation of aromatase expression in the breast by AMPK and CRTC2, in response to the altered adipokine milieu associated with obesity, provides an important link between obesity and breast cancer risk.
Formal Description
Interaction-ID: 2840

complex/PPI

AMPK

affects_expression of

gene/protein

CYP19A1

Drugbank entries Show/Hide entries for CYP19A1
Comment The regulation of aromatase expression in the breast by AMPK and CRTC2, in response to the altered adipokine milieu associated with obesity, provides an important link between obesity and breast cancer risk.
Formal Description
Interaction-ID: 12828

gene/protein

CRTC2

affects_expression of

gene/protein

CYP19A1

Drugbank entries Show/Hide entries for CYP19A1
Comment The regulation of aromatase expression in the breast by AMPK and CRTC2, in response to the altered adipokine milieu associated with obesity, provides an important link between obesity and breast cancer risk.
Formal Description
Interaction-ID: 12829

gene/protein

Cytokine

affects_activity of

complex/PPI

AMPK

Comment The regulation of aromatase expression in the breast by AMPK and CRTC2, in response to the altered adipokine milieu associated with obesity, provides an important link between obesity and breast cancer risk.
Formal Description
Interaction-ID: 12830

gene/protein

Cytokine

affects_activity of

gene/protein

CRTC2

Comment The regulation of aromatase expression in the breast by AMPK and CRTC2, in response to the altered adipokine milieu associated with obesity, provides an important link between obesity and breast cancer risk.
Formal Description
Interaction-ID: 12831

disease

Obesity

affects_activity of

gene/protein

Cytokine