General Information:

Id: 545 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
article
Reference: Goni-Oliver P et al.(2009) Memantine inhibits calpain-mediated truncation of GSK-3 induced by NMDA: implications in Alzheimers disease J. Alzheimers Dis. 18: 843-848 [PMID: 19661623]

Interaction Information:

Comment Calpain-mediated GSK-3 truncation, induced by N-methyl-D-aspartic acid (NMDA), depends on extracellular calcium. Calcium influx through NMDA receptors induces GSK-3 proteolysis.
Formal Description
Interaction-ID: 2768

drug/chemical compound

Ca2+

affects_quantity of

protein modification

GSK3B (truncated)

via GSK3 proteolysis