General Information:

Id: 5,451 (click here to show other Interactions for entry)
Diseases: Metabolic
Homo sapiens
HepG2 cell; A549 cell; H1299 cell
article
Reference: Roudier E et al.(2006) Statins induce mammalian target of rapamycin (mTOR)-mediated inhibition of Akt signaling and sensitize p53-deficient cells to cytostatic drugs Mol. Cancer Ther. 5: 2706-2715 [PMID: 17121917]

Interaction Information:

Comment Insulin – and cytostatic drug – induced Akt phosphorylation and nuclear translocation was inhibited by pravastatin and atorvastatin in HepG2, A549, and H1299 cells in an mTOR-dependent manner. This effect can be counteracted in p53 competent cells by the ability of statins to destabilize p53.
Formal Description
Interaction-ID: 53202

drug/chemical compound

Atorvastatin

decreases_phosphorylation of

gene/protein

AKT1

insulin- and cytostatic drug-induced Akt phosphorylation
Drugbank entries Show/Hide entries for Atorvastatin or AKT1