General Information:

Id: 543 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0000567 HeLa cell; BTO:0000793 SH-SY5Y cell
article
Reference: Geisler S et al.(2010) PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1 Nat. Cell Biol. 12: 119-131 [PMID: 20098416]

Interaction Information:

Comment Partial silencing of VDAC1 resulted in significantly reduced translocation of Parkin from the cytosol to damaged mitochondria after 2 h of CCCP treatment. After 24 h of CCCP treatment, partial knockdown of VDAC1 also significantly prevented mitochondrial clearance.
Formal Description
Interaction-ID: 2857

gene/protein

VDAC1

affects transport of

gene/protein

PARK2

into mitochondria; after CCCP treatment
Drugbank entries Show/Hide entries for VDAC1