General Information:

Id: 543 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0000567 HeLa cell; BTO:0000793 SH-SY5Y cell
article
Reference: Geisler S et al.(2010) PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1 Nat. Cell Biol. 12: 119-131 [PMID: 20098416]

Interaction Information:

Comment VDAC1 is ubiquitylated in a Parkin-dependent manner after CCCP treatment. None of the analysed pathogenic Parkin mutants were able to modify VDAC1.
Formal Description
Interaction-ID: 2850

gene/protein

PARK2

increases_ubiquitination/sumoylation of

gene/protein

VDAC1

after CCCP treatment
Drugbank entries Show/Hide entries for VDAC1