General Information:

Id: 543 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0000567 HeLa cell; BTO:0000793 SH-SY5Y cell
article
Reference: Geisler S et al.(2010) PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1 Nat. Cell Biol. 12: 119-131 [PMID: 20098416]

Interaction Information:

Comment Treatment with the uncoupler CCCP induced complete translocation of transfected Parkin from the cytoplasm to depolarized mitochondria. Parkin localized to mitochondria induces mitophagy.
Formal Description
Interaction-ID: 2744

drug/chemical compound

CCCP

increases_transport of

gene/protein

PARK2

into mitochondria