General Information:

Id: 5,435 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Retinopathy, diabetic
Homo sapiens
BTO:0002335 ARPE-19 cell
article
Reference: Zhou T et al.(2011) The role of lipid peroxidation products and oxidative stress in activation of the canonical wingless-type MMTV integration site (WNT) pathway in a rat model of diabetic retinopathy Diabetologia 54: 459-468 [PMID: 20978740]

Interaction Information:

Comment N-Acetyl-cysteine (NAC) is a glutathione precursor and increases glutathione levels. A previous study reported that WNT or its related signalling proteins are the major targets of glutathione action. ARPE19 cells were exposed to WNT3A-conditioned medium with or without NAC for 6 h. Measurement of glutathione showed that NAC treatment induced a significant increase of glutathione levels. NAC blocked WNT3A-induced TOPFLASH activity. WNT3A induced a 2.5-fold increase of LRP6 phosphorylation, which was attenuated by NAC.
Formal Description
Interaction-ID: 53041

drug/chemical compound

Acetylcysteine

increases_quantity of

drug/chemical compound

Glutathione

Drugbank entries Show/Hide entries for Acetylcysteine or Glutathione