General Information:

Id: 5,425 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Retinopathy, diabetic
Homo sapiens
BTO:0002335 ARPE-19 cell
article
Reference: Liu Q et al.(2013) Nitrosative stress plays an important role in Wnt pathway activation in diabetic retinopathy Antioxid. Redox Signal. 18: 1141-1153 [PMID: 23066786]

Interaction Information:

Comment Elevated levels of phosphorylated LRP6 and nonphosphorylated beta-catenin were observed at 20 min of peroxynitrite (PN) treatment, demonstrating activation of the Wnt pathway. The Wnt signaling induced by PN was significantly attenuated by uric acid (UA), a natural scavenger of PN. These results suggested that nitrosative stress contributes to activation of the Wnt-signaling pathway.
Formal Description
Interaction-ID: 52979

drug/chemical compound

Peroxynitrite

increases_activity of

Comment Elevated levels of phosphorylated LRP6 and nonphosphorylated beta-catenin were observed at 20 min of peroxynitrite (PN) treatment, demonstrating activation of the Wnt pathway. The Wnt signaling induced by PN was significantly attenuated by uric acid (UA), a natural scavenger of PN. These results suggested that nitrosative stress contributes to activation of the Wnt-signaling pathway.
Formal Description
Interaction-ID: 52980

drug/chemical compound

Urate

decreases_activity of

if Wnt signaling is induced by peroxynitrite
Comment Uric acid (UA) inhibits the Wnt-signaling pathway activation induced by 4-Hydroxynonenal (HNE.
Formal Description
Interaction-ID: 52988

drug/chemical compound

4-Hydroxynonenal

increases_activity of

Comment To further investigate whether uric acid (UA) inhibits high glucose (HG)-induced activation of Wnt signaling, ARPE19 cells and human retinal Muller cells (HMC) were cultured with HG for and subsequently treated with different concentrations of UA. UA inhibited HG-induced LRP6 phosphorylation in a concentration- dependent manner in both ARPE19 cells and HMC. Phosphorylation of beta-catenin is the initial step for its degradation. Phosphorylated beta-catenin (p-beta-catenin) was significantly decreased by HG, which resulted in subsequent increases of both cytosolic and nuclear beta-catenin levels in ARPE19 cells. These changes of beta-catenin induced by HG were reversed by UA.
Formal Description
Interaction-ID: 52997

phenotype

hyperglycemia

increases_activity of