Welcome to cider

Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	5,425 (click here to show other Interactions for entry)
Diseases:	Diabetes mellitus, type II - [OMIM] Insulin resistance Retinopathy, diabetic
Organism:	Homo sapiens
Tissue/Cell line:	BTO:0002335 ARPE-19 cell
Publication type:	article
Reference:	Liu Q et al.(2013) Nitrosative stress plays an important role in Wnt pathway activation in diabetic retinopathy Antioxid. Redox Signal. 18: 1141-1153 [PMID: 23066786]

Interaction Information:

Comment	Elevated levels of phosphorylated LRP6 and nonphosphorylated beta-catenin were observed at 20 min of peroxynitrite (PN) treatment, demonstrating activation of the Wnt pathway. The Wnt signaling induced by PN was significantly attenuated by uric acid (UA), a natural scavenger of PN. These results suggested that nitrosative stress contributes to activation of the Wnt-signaling pathway.
Formal Description Interaction-ID: 52979	drug/chemical compound Peroxynitrite increases_activity of process canonical Wnt signaling pathway

Home
Contact

The Helmholtz Zentrum München Imprint and Privacy Policy apply.

© 2013 - Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH) Ingolstädter Landstraße 1, D-85764 Neuherberg, Germany

Disclaimer: IBIS Databases and associated information are protected by copyright. This server and its associated data and services are for academic, non-commercial use only. The Helmholtz Zentrum München has no liability for the use of results, data or information which have been provided through this server. Neither the use for commercial purposes, nor the redistribution of IBIS database files to third parties nor the distribution of parts of files or derivative products to any third parties is permitted. Commercial users shall contact the Helmholtz Zentrum München for a separate users license.