General Information:

Id: 5,414 (click here to show other Interactions for entry)
Diseases: Metabolic
Mammalia
article
Reference: Zhou F et al.(2012) The APP intracellular domain (AICD) inhibits Wnt signalling and promotes neurite outgrowth Biochim. Biophys. Acta 1823: 1233-1241 [PMID: 22613765]

Interaction Information:

Comment AICD strongly inhibits Wnt-induced transcriptional reporter activity and counteracts Wnt-induced c-Myc expression. Loss of the AICD resulted in an increased responsiveness to Wnt/beta-catenin-mediated transcription. AICD can inhibit Wnt signalling induced by LRP6, Dishevelled1/2/3 and beta-catenin wild-type (wt) and may antagonise Wnt signalling in a beta-catenin destruction complex-dependent manner.
Formal Description
Interaction-ID: 52882

gene/protein

APP (intracellular domain AICD)

decreases_activity of

process

canonical Wnt signaling pathway

if induced by LRP6, Dishevelled1/2/3 and beta-catenin wild-type (wt);