General Information:

Id: 5,413 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
male
article
Reference: Jiang Y et al.(2014) Pravastatin prevents steroid-induced osteonecrosis in rats by suppressing PPARgamma expression and activating Wnt signaling pathway Exp. Biol. Med. (Maywood) 239: 347-355 [PMID: 24510055]

Interaction Information:

Comment Steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH) is characterized by increase of intraosseous pressure because of lipid metabolism disturbance such as elevation of adipogenesis and fat cell hypertrophy in the bone marrow, subsequently leading to disturbances of coagulation-fibrinolysis system in the femoral head and finally resulting in bone ischemia. Pravastatin treatment could prevent steroid-induced ONFH by suppressing the expression of PPARgamma, and increasing the expression of Wnt3a, LRP5, beta-catenin, and RUNX2, at both mRNA and protein levels, in the femoral heads of steroid-induced ONFH rats. Pravastatin may prevent steroid-induced ONFH by suppressing PPARgamma expression and activating Wnt signaling pathway.
Formal Description
Interaction-ID: 52878

drug/chemical compound

Pravastatin

increases_expression of

gene/protein

CTNNB1

in femoral head
Drugbank entries Show/Hide entries for Pravastatin or CTNNB1