General Information:

Id: 5,413
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
male
article
Reference: Jiang Y et al.(2014) Pravastatin prevents steroid-induced osteonecrosis in rats by suppressing PPARgamma expression and activating Wnt signaling pathway Exp. Biol. Med. (Maywood) 239: 347-355 [PMID: 24510055]

Interaction Information:

Comment Steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH) is characterized by increase of intraosseous pressure because of lipid metabolism disturbance such as elevation of adipogenesis and fat cell hypertrophy in the bone marrow, subsequently leading to disturbances of coagulation-fibrinolysis system in the femoral head and finally resulting in bone ischemia. Pravastatin treatment could prevent steroid-induced ONFH by suppressing the expression of PPARgamma, and increasing the expression of Wnt3a, LRP5, beta-catenin, and RUNX2, at both mRNA and protein levels, in the femoral heads of steroid-induced ONFH rats. Pravastatin may prevent steroid-induced ONFH by suppressing PPARgamma expression and activating Wnt signaling pathway.
Formal Description
Interaction-ID: 52827

drug/chemical compound

Pravastatin

decreases_activity of

disease

Steroid-induced osteonecrosis of the femoral head

Drugbank entries Show/Hide entries for Pravastatin
Comment Steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH) is characterized by increase of intraosseous pressure because of lipid metabolism disturbance such as elevation of adipogenesis and fat cell hypertrophy in the bone marrow, subsequently leading to disturbances of coagulation-fibrinolysis system in the femoral head and finally resulting in bone ischemia. Pravastatin treatment could prevent steroid-induced ONFH by suppressing the expression of PPARgamma, and increasing the expression of Wnt3a, LRP5, beta-catenin, and RUNX2, at both mRNA and protein levels, in the femoral heads of steroid-induced ONFH rats. Pravastatin may prevent steroid-induced ONFH by suppressing PPARgamma expression and activating Wnt signaling pathway.
Formal Description
Interaction-ID: 52875

drug/chemical compound

Pravastatin

decreases_expression of

gene/protein

PPARG

in femoral head
Drugbank entries Show/Hide entries for Pravastatin or PPARG
Comment Steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH) is characterized by increase of intraosseous pressure because of lipid metabolism disturbance such as elevation of adipogenesis and fat cell hypertrophy in the bone marrow, subsequently leading to disturbances of coagulation-fibrinolysis system in the femoral head and finally resulting in bone ischemia. Pravastatin treatment could prevent steroid-induced ONFH by suppressing the expression of PPARgamma, and increasing the expression of Wnt3a, LRP5, beta-catenin, and RUNX2, at both mRNA and protein levels, in the femoral heads of steroid-induced ONFH rats. Pravastatin may prevent steroid-induced ONFH by suppressing PPARgamma expression and activating Wnt signaling pathway.
Formal Description
Interaction-ID: 52876

drug/chemical compound

Pravastatin

increases_expression of

gene/protein

WNT3A

in femoral head
Drugbank entries Show/Hide entries for Pravastatin
Comment Steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH) is characterized by increase of intraosseous pressure because of lipid metabolism disturbance such as elevation of adipogenesis and fat cell hypertrophy in the bone marrow, subsequently leading to disturbances of coagulation-fibrinolysis system in the femoral head and finally resulting in bone ischemia. Pravastatin treatment could prevent steroid-induced ONFH by suppressing the expression of PPARgamma, and increasing the expression of Wnt3a, LRP5, beta-catenin, and RUNX2, at both mRNA and protein levels, in the femoral heads of steroid-induced ONFH rats. Pravastatin may prevent steroid-induced ONFH by suppressing PPARgamma expression and activating Wnt signaling pathway.
Formal Description
Interaction-ID: 52877

drug/chemical compound

Pravastatin

increases_expression of

gene/protein

LRP5

in femoral head
Drugbank entries Show/Hide entries for Pravastatin
Comment Steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH) is characterized by increase of intraosseous pressure because of lipid metabolism disturbance such as elevation of adipogenesis and fat cell hypertrophy in the bone marrow, subsequently leading to disturbances of coagulation-fibrinolysis system in the femoral head and finally resulting in bone ischemia. Pravastatin treatment could prevent steroid-induced ONFH by suppressing the expression of PPARgamma, and increasing the expression of Wnt3a, LRP5, beta-catenin, and RUNX2, at both mRNA and protein levels, in the femoral heads of steroid-induced ONFH rats. Pravastatin may prevent steroid-induced ONFH by suppressing PPARgamma expression and activating Wnt signaling pathway.
Formal Description
Interaction-ID: 52878

drug/chemical compound

Pravastatin

increases_expression of

gene/protein

CTNNB1

in femoral head
Drugbank entries Show/Hide entries for Pravastatin or CTNNB1
Comment Steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH) is characterized by increase of intraosseous pressure because of lipid metabolism disturbance such as elevation of adipogenesis and fat cell hypertrophy in the bone marrow, subsequently leading to disturbances of coagulation-fibrinolysis system in the femoral head and finally resulting in bone ischemia. Pravastatin treatment could prevent steroid-induced ONFH by suppressing the expression of PPARgamma, and increasing the expression of Wnt3a, LRP5, beta-catenin, and RUNX2, at both mRNA and protein levels, in the femoral heads of steroid-induced ONFH rats. Pravastatin may prevent steroid-induced ONFH by suppressing PPARgamma expression and activating Wnt signaling pathway.
Formal Description
Interaction-ID: 52879

drug/chemical compound

Pravastatin

increases_expression of

gene/protein

RUNX2

in femoral head
Drugbank entries Show/Hide entries for Pravastatin
Comment Steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH) is characterized by increase of intraosseous pressure because of lipid metabolism disturbance such as elevation of adipogenesis and fat cell hypertrophy in the bone marrow, subsequently leading to disturbances of coagulation-fibrinolysis system in the femoral head and finally resulting in bone ischemia. Pravastatin treatment could prevent steroid-induced ONFH by suppressing the expression of PPARgamma, and increasing the expression of Wnt3a, LRP5, beta-catenin, and RUNX2, at both mRNA and protein levels, in the femoral heads of steroid-induced ONFH rats. Pravastatin may prevent steroid-induced ONFH by suppressing PPARgamma expression and activating Wnt signaling pathway.
Formal Description
Interaction-ID: 52880

drug/chemical compound

Pravastatin

increases_activity of

Drugbank entries Show/Hide entries for Pravastatin
Comment Pravastatin administration improves hyperlipidemia in steroid-induced ONFH rats.
Formal Description
Interaction-ID: 52881

drug/chemical compound

Pravastatin

decreases_activity of

phenotype

hyperlipidemia

in steroid-induced osteonecrosis of the femoral head
Drugbank entries Show/Hide entries for Pravastatin